SMART ChromatographyTM has been designed to allow for rapid and cost-effective purification of biomolecules directly from the cell culture system.
Designed to be truly linearly scalable, SMART ChromatographyTM offers the purification scientist a familiar packed-bed chromatography column format that does not require any removal of cell mass (cells, cell debris, etc.) prior to application of the feed stream to the purification column. By exploiting the advantages of radial flow chromatography and combining it with ZetaCell solid phases, processes may be fully developed in the R&D laboratory before transfer to large-scale manufacturing without any modification to the process.
emp Biotech has developed the ZetaCell range of solid phases which allow the user to select the correct resin for their application, be it ion-exchange (IEX), hydrophobic interaction (HIC) or immuno-affinity. We also offer an activated solid phase to allow the user to create their own functionalised solid phase.
The company has developed SMART ChromatographyTM to assist the purification scientist in developing and operating more efficient and cost-effective processes. We will present data demonstrating the efficiency of the system with real world applications on both bacterial and mammalian cell systems.
When compared to traditional processes, purification times can be reduced from >24 hours to as little as 2½ hours.