Nagaraj S Moily
Nagaraj S Moily, M.B.B.S,
Dept. of Biochemistry and Molecular Biology
Bio21 Institute, The University of Melbourne
Parkville VIC 3010
Email: nmoily@student.unimelb.edu.au
Phone: 0424833455 / (03) 8344 2311
CURRENT POSITION:Working with Dr Danny Hatters, Dr Anthony J Hannan and Dr Kathryn E Holt on “defining how pathogenic Htt aggregation state alters the transcriptome.”
This project will define and validate how aggregation state of PolyQ impacts gene expression, transcription and other cellular functions and is expected to provide a rich source of information with potential to unmask new pathways to mechanisms of dysfunction. We also expect to define and validate how aggregation state affects gene expression changes in human HD pathology, and conversely the role these gene expressions have on the aggregation phenomenon. Finding successful modifiers of toxicity affected by aggregation state would provide new therapeutic targets for further testing.
RESEARCH EXPERIENCE:
2010 (October) to (November) 2013: Research associate in “Generativity in cognitive networks” at National Centre for Biological Sciences, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore under Dr. Sanjeev Jain and Dr. John P John
Role: Involved in structural and functional imaging of evoked emotions in individuals with emotional perturbations and genetic correlation of risk SNP’s of biogenic amines with the volumetric changes in amygdala and hippocampus at the Multimodal Brain Imaging Laboratory at NIMHANS in collaboration with National Centre for Biological Sciences
2008(December) to 2010(September): Working on Genotype and Phenotype Correlates in Huntington’s disease and Spinocerebellar Ataxia in the Genetic Counseling and Testing Clinic at the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore
Clinical role - actively involved in the genetic testing and counseling of patients from the Movement Disorder Clinic and Clinical management of patients at Genetic testing and counseling clinics (GCAT) at NIMHANS
Laboratory role - Accurate sizing of Ataxia and Huntingtin gene loci, Haplotype analysis and analysis of other interacting loci of Huntington disease I am also working on neuro-imaging in spinocerebellar ataxia (SCA) and generation of disease specific cell lines with the aim of correlating the effect on genes on the phenotypic biomarkers of these disorders.
Research associate in “Development of Pharmacogenomics - SNP database for critical candidate genes involved in drug response in schizophrenia” at Molecular Genetics Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore under Dr. Sanjeev Jain
Role: Involved in the recruitment of clinical samples and analysis of SNPs in a panel of candidate genes (drug metabolism enzymes, targets /receptors, transporters and other relevant genes) involved in drug response to specific antipsychotics in patients and healthy populations. New potential leads for personalized predictive therapy (medicine) for schizophrenia in Indian population were identified in this project and are being published in various international peer reviewed journals
2008(September) to 2008(November): Research assistant in Centre for Advanced Neurological Research, K.S. Hegde Medical Academy, Deralkatte, Mangalore under Dr Lekha Pandit
Role: trainee –Introduced to the basics of molecular genetics
QUALIFICATION:
2007(May) to May (2008): Residency – rotatory houseman ship at K.S. Hegde Medical Academy, Deralkatte, Mangalore.
Role: Clinical resident -Assessment, investigations and management of general medical and surgical conditions, with additional elective rotations in Psychiatry and Neurology departments
2002(May) to 2007(May): M.B.B.S (Bachelor of Medicine, Bachelor of Surgery)
Rajiv Gandhi University of health sciences Bangalore, India (Feb -2008)
RELEVANT PUBLICATIONS:
JOURNALS (PEER REVIEWED)
Meenal Guptaa, Nagaraj Moilyb, Harpreet Kaur, Ajay Jajodia, Sanjeev Jain, Ritushree Kukreti (February - 2013) .Identifying a predictive model for response to atypical antipsychotic monotherapy treatment in south Indian schizophrenia patients. Genomics, Available online 8 February 2013, ISSN 0888-7543, DOI - 10.1016/ j.ygeno.2013.02.002 (Impact factor -3.019)
Danivas V, Moily NS, Thimmaiah R, Muralidharan K, Purushotham M, Muthane U, Jain S (January 2013). Off label use of lithium in the treatment of Huntington's disease: A case series. Indian journal of Psychiatry - Indian J Psychiatry 2013;55: 81-3. DOI: 10.4103/0019-5545.105522
Gupta, M., Jain, S., Moily, N. S., Kaur, H., Jajodia, A., Purushottam, M. and Kukreti, R. (2012), Genetic studies indicate a potential target 5-HTR3B for Drug Therapy in Schizophrenia Patients. American Journal of Medical Genetics – Neuropsychiatry Genetics (December 2012) - Am. J. Med. Genet., 159B: 1006–1008. DOI: 10.1002/ajmg.b.32105 (Impact factor – 3.72)
Triplet repeat expansion at the Huntingtin loci in India. Nagaraj S. Moily, Mahesh Kandasamy, Lakshmi Narayanan Kota , Ram Murthy Anjanappa , V. Sowmya, Radhika Vaidyanathan , Pramod Kumar Pal, Meera Purushottam, Sanjeev Jain. (Submitted under review – Indian Journal of Medical research)
Telomere length in Huntington Disease. Meera Purushottam, Lakshmi Narayanan Kota, Nagaraj S Moily, Srikala Bharath, Pramod Kumar Pal, Sanjeev Jain (resubmitted under review– Movement Disorder).
Telomere length in schizophrenia and dementia. Lakshmi Narayanan Kota, Meera Purushottam, Nagaraj S Moily, Bhavani Shankara Bagepally, Palanimuthu Thangaraju Sivakumar, Mathew Varghese, Srikala Bharath, Sanjeev Jain. (under review– Schizophrenia research).
A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses. Nagaraj S. Moily; Ammu Lukose; Bhavani Shankara Bagepally; Harsha N. Halahalli; Anupa A V; Sanjeev Jain; John P. John (submitted under review – Psychiatry and Clinical Neurosciences).
A comprehensive approach for identifying role of chromosome22q11 haplotypes in antipsychotic drug response. Meenal Gupta, Nagaraj S Moily, Sanjeev Jain, Harpreet Kaur, Ajay Jajodia, Meera Purushottam, Ritushree Kukreti (under review- Future Medicine Pharmacogenomics).
Association study of GRIN1, ABCB1 and DRD4 Gene Polymorphisms with Schizophrenia and Response to Risperidone and Olanzapine Treatment. Pranita Pai, Praveen Arathil, Rajesh Nair, Meenal Guptaa, Nagaraj S Moily, PSVN Sharma, Ritushree Kukreti, Sanjeev Jain, Padmalatha Rai S, Gopinath PM, Satyamoorthy K (under review- Pharmacogenomics).
Does latitude as a zeitgeber affect the course of bipolar affective disorder? Janardhanan C. Narayanaswamy, Nagaraj Moily, Shobana Kubendran, YC Janardhan Reddy, Sanjeev Jain (Submitted to Journal of Medical Hypotheses)
Effect of COMT, 5-HT2A and 5-HTTLPR polymorphisms on brain morphometry in schizophrenia and healthy subjects. Anupa AV, John JP ,Halahalli HN, Bagepally BS, Pradeep P,Thirunavakkarasu P, Moily N, Purushottam M, Jain S.
MONOGRAPHS:
Moily NS, Purushottam M, Pal PK, Jain S (June 2012). Huntington’s disease, In: Sinha KK, Jha DK, editors. Monograph on Movement Disorders, pp 213-234. Publishers - The association of physicians of India: Indian college of physicians.
REFEREED CONFERENCE PAPERS:
Anupa AV, John JP ,Halahalli HN, Bagepally BS, Pradeep P,Thirunavakkarasu P, Moily N, Purushottam M, Jain S. Effect of COMT, 5-HT2A and 5-HTTLPR polymorphisms on brain morphometry in schizophrenia and healthy subjects. Submitted to the Annual Conference on Cognitive Science (ACCS 2014), New Delhi.
Nagaraj S. Moily, Mahesh Kandasamy, Ram Murthy, Lakshmi Narayanan, Radhika
Vaidyanathan, Sowmya Devi, Pramod Pal, Meera Purushottam, Sanjeev Jain. Distribution of CAG Expansion at the Huntingtin Locus in India. Presented at the XXI World Congress of Psychiatric Genetics, Massachusetts, Boston USA organized by the International Society for Psychiatric Genetics (October 2013)
Lakshmi Narayanan Kota*, Nagaraj. S. Moily*, Meera Purushottam, Srikala Bharath, Palanimuthu Thangaraju Sivakumar, Mathew Varghese, Sanjeev Jain. Telomere length as relative T/S ratios in psychiatric and degenerative disorders. Presented at the XXI World Congress of Psychiatric Genetics, Massachusetts, Boston USA organized by the International Society for Psychiatric Genetics (October 2013)
M. Purushottam, L. N Kota, N .S Moily, S. Bharath, P.K Pal, S Jain (2013). “Telomere length in Huntington’s Disease” - The Joint Conference of Human Genome Meeting and 21st International Congress of Genetics (HGN-ICG), Singapore
K.R. Jhavar, P.K. Pal, M.S. Nagaraj, R. Yadav, S. Jain, J. Saini, M. Purushottam (2011). “A clinical and genetic profile of 17 patients with Huntington’s Disease seen in Southern India” - presented at Movement disorder Society 15th international congress on Parkinson’s disease and movement disorder held at Toronto, Canada
Nagaraj SM1, Kota LN1, Meera P1, Pramod Pal2, Sanjeev Jain1 (2011). “Clinical and genetic profile of Huntington’s disease in India”- ; presented at the International Conference on “Genomics, Genetic Diseases and Diagnostics” and XXXVI Annual Conference of The Indian Society of Human Genetics held at Manipal Life Sciences Centre, Manipal University, Manipal, India
Nagaraj S Moily1, Bhavani Shankar2, Hyder Usman1, Nagashree1,Srinivas1, Meera Purushottam2, Mathew Varghese2,JPJohn1, Sanjeev Jain2 & Odity Mukherjee1 (2010). “Graying India – Genetic Architecture of Alzheimer’s disease Related Genes” – Joint Conference of NIMHANS and the Royal College of Psychiatrists, United Kingdom at NIMHANS
Nagaraj S Moily, Srinivasa Rao, Sateesha Rao (2007).“A study on the knowledge and attitude regarding psychiatric illness among faith healers” – presented at the Annual Conference of the Karnataka Chapter of Indian psychiatric society held at Belgaum Karnataka (2007)
AWARDS:
Early Career Investigator Program and travel award from International Society for Psychiatric Genetics(ISPG) – National Institute of Mental Health(NIMH), Bethesda USA (October 2013)
MEMBERSHIPS:
International Brain Research Organization(IBRO)
International Society for Psychiatric Genetics(ISPG)
RESEARCH WORKSHOPS/TRAINING:
Successfully completed the NIBMG-EBI Winter School on Analysis of Massively-Parallel Sequencing Data jointly organized by the National Institute of Biomedical Genomics and European Molecular Biology Laboratory –European Bioinformatics Institute (EMBL-EBI), sponsored by the British High Commission at Kalyani, West Bengal from January 7th – January 12th 2013.
Successfully completed an advanced workshop in “Data analysis technique for functional brain mapping using MRI”, at National institute of mental health and neurosciences, Bangalore (2011).
Completed advanced training in “Genome analysis using Genetic Analyzer”, at the state of art training facility of Invitrogen Biosciences Gurgaon, Haryana, India (2011).
“Teaching Course in Cognitive Neurology” organized by World Federation of Neurology
Research group on Aphasia and Cognitive disorders (WFN RGACD) and Department of
Neurology, Nizam's Institute of Medical Sciences Hyderabad (2011)
NCBS – Edinburgh Neuroscience Alliance workshop on “Neurodevelopmental Disorders and Neuroinformatics” organized by NCBS and Science and Innovation network, University of Edinburgh (2011).
Fifth India-U.S.A Workshop on “Genetic Epidemiological Methods for Dissection of Complex Human Traits” organized by TCG-ISI Centre for Population Genomics & University of Pittsburgh (2010)
Indo– US workshop on Epigenetic regulation and Genome Control, focus on RNAi and
micro RNA , Centre for Cellular and Microbiology (CCMB),Hyderabad (2009)
INCF Workshop on Multi-scale Modeling, neuro-informatics in neurobiology at the National centre for biological sciences (NCBS), Bangalore (2009)